Etanercept attenuates traumatic brain injury in rats by reducing brain TNF-alpha contents and by stimulating newly formed neurogenesis.
RatTBIFluid percussionSprague-DawleyMalen = n = 8 per group across three groupsIntraperitoneal0.1 mg/kgImmediately after injury
Model: Lateral fluid percussion injury through a 4.8 mm craniotomy 3.0 mm right of the central suture
Etanercept was detectable in contused brain tissue and reduced neurological and motor deficits, contusion area and brain TNF-alpha while increasing BrdU and doublecortin double-positive cells.
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