Acute lethal crush-injured rats can be successfully rescued by a single injection of high-dose dexamethasone through a pathway involving PI3K-Akt-eNOS signaling.
RatCrushLimb / muscle crushWistarMaleIntravenousLow dose 0.1 mg/kg and high dose 5.0 mg/kgImmediately before reperfusion, after 5 h of compression
Model: Crush syndrome by bilateral hind limb compression with rubber tourniquets for 5 h followed by reperfusion
Untreated crush syndrome caused 76% mortality by 48 h, whereas a single high-dose dexamethasone injection before reperfusion activated PI3K-Akt-eNOS signalling, suppressed systemic inflammation and improved survival.
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