Immediate splenectomy down-regulates the MAPK-NF-kappaB signaling pathway in rat brain after severe traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleSurgicalImmediately after injury
Model: Severe traumatic brain injury rat model
Immediate splenectomy suppressed injury-induced cerebral MAPK activation, and interleukin-1 receptor antagonist reduced spleen supernatant-driven MAPK activation, NF-kappaB translocation and neuronal apoptosis in vitro.
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