THERAPY DOSSIER · th-9fd3117a44a7

Immediate splenectomy

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

7 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07274007 ↗Injury indicationNAactive not recruiting

Grade III traumatic splenic injury in haemodynamically stable patients: laparoscopic splenectomy versus splenic artery embolisation

Grade III traumatic splenic injury

Enrolment: 24 · Results not recorded

NCT04329845 ↗Injury indicationNAcompleted

Laparoscopic versus open splenectomy in isolated high-grade splenic injury, blunt abdominal trauma (RCT)

Laparoscopic surgery · Splenic injury

Enrolment: 2 · Results not recorded

NCT02021396 ↗Injury indicationNAcompleted

Prophylactic embolisation for splenic salvage in trauma patients at high risk of splenectomy

Splenic trauma

Enrolment: 140 · Results not recorded

NCT03420599 ↗Injury indicationPhase not recordedunknown

Altered microbiota and increased infection rates after traumatic splenectomy

Gut microbiota · Spleen injury · Infection

Enrolment: 80 · Results not recorded

NCT03648307 ↗Injury indicationPhase not recordedcompleted

Long-term effect of splenectomy on metabolism, retrospective cohort

Trauma splenic

Enrolment: 154 · Results not recorded

NCT01965548 ↗Injury indicationPhase not recordedcompleted

Treatment of splenic trauma: a retrospective cohort study

Splenic injury

Enrolment: 109 · Results not recorded

NCT06334263 ↗Injury indicationPhase not recordedrecruiting

Decision to treat acute traumatic splenic artery injury in the context of trauma

Trauma · Spleen injury

Enrolment: 8000 · Results not recorded

NCT02232191 ↗PHASE2recruiting

Immunologic response to pneumococcal polysaccharide vaccine in splenic injury patients

Asplenia

Enrolment: 75 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23694871 ↗2013Reported benefit

Immediate splenectomy down-regulates the MAPK-NF-kappaB signaling pathway in rat brain after severe traumatic brain injury.

RatTBIUnspecifiedSprague-DawleyMaleSurgicalImmediately after injury

Model: Severe traumatic brain injury rat model

Immediate splenectomy suppressed injury-induced cerebral MAPK activation, and interleukin-1 receptor antagonist reduced spleen supernatant-driven MAPK activation, NF-kappaB translocation and neuronal apoptosis in vitro.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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