Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
MouseChemical/toxinMaleOral administration100 and 200 mg/kgPre-treatment for 7 days before acetaminophen challenge
Model: Acetaminophen-induced acute liver injury (350 mg/kg acetaminophen intraperitoneally)
Apigenin pre-treatment lowered serum alanine aminotransferase and aspartate aminotransferase and reduced the severity of liver injury, with significant changes in liver necrosis at 200 mg/kg. Hepatic glutathione reductase activity and reduced glutathione content increased and malondialdehyde decrea…
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