Tocopherol supplementation reduces NO production and pulmonary inflammatory response to bleomycin.
MouseChemical/toxinC57BL/6JMaleDietary (oral, ad libitum)0.3% gammaTmT diet, the mixture containing per gram 130 mg…Dietary supplementation established before intratracheal bleomycin instillation…
Model: Intratracheal bleomycin sulfate instillation at 2 units/kg (acute lung injury)
Dietary tocopherol raised lung and serum tocopherol levels, prevented the bleomycin-induced rise in nitrite and nitrate, reduced lavage chemotactic potential and limited histological inflammation, and shifted macrophage activation towards an alternative phenotype. Injury itself was not prevented: t…
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