Gamma tocopherol-enriched supplement on lower airway responses to inhaled wood smoke
Airway inflammation · Asthma
Enrolment: 16 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Airway inflammation · Asthma
Enrolment: 16 · Results not recorded
Mild allergic asthma
Enrolment: 23 · Results not recorded
Endothelial dysfunction
Enrolment: 67 · Results not recorded
Chronic kidney disease
Enrolment: 62 · Results not recorded
Allergic rhinitis · Mild asthma
Enrolment: 8 · Results not recorded
Healthy
Enrolment: 18 · Results not recorded
Allergic · Asthmatic · Allergy · Asthma
Enrolment: 25 · Results not recorded
Gamma Tocopherol Serum Levels
Enrolment: 10 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Intratracheal bleomycin sulfate instillation at 2 units/kg (acute lung injury)
Dietary tocopherol raised lung and serum tocopherol levels, prevented the bleomycin-induced rise in nitrite and nitrate, reduced lavage chemotactic potential and limited histological inflammation, and shifted macrophage activation towards an alternative phenotype. Injury itself was not prevented: t…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Intranasal instillation of lipopolysaccharide in pyrogen-free saline, 150 microlitres into each nasal passage (300 microlitres total) at a total dose of 0, 5 or 20 micrograms (2500 and 10,000 endotoxin units) under light isoflurane anaesthesia, repeated 24 hours later, with tissues collected 24 hours after the last dose
Gamma-tocopherol raised plasma vitamin E four to five fold to about 1.5 micromolar and returned lavage neutrophils, macrophages, protein, prostaglandin E2 and secreted mucins towards control values, normalised the 230 and 900 per cent increases in proximal and distal airway intraepithelial mucosubs…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.