17beta-estradiol confers protection after traumatic brain injury in the rat and involves activation of G protein-coupled estrogen receptor 1.
RatTBIFluid percussionSprague-DawleyMaleIntravenous bolus17beta-estradiol given at several doses, with 5 mg/kg produ…1 h post-injury
Model: Lateral fluid percussion traumatic brain injury
A single intravenous bolus of 17beta-estradiol or G-1 given 1 h after lateral fluid percussion injury increased neuronal survival in the ipsilateral CA2/3 hippocampus and reduced neuronal degeneration, apoptotic cell death and astrogliosis at 24 h. Effects were dose-dependent for 17beta-estradiol.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.