Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models.
RatOtherSprague-DawleyMaleIntraperitoneal0.5 to 1.5 mg/kgFourteen days after nerve injury in the chronic constriction injury model
Model: Chronic constriction injury of the sciatic nerve; separate neuropathy models induced by intravenous dideoxycytidine (25 mg/kg) and repeated intraperitoneal oxaliplatin (2.4 mg/kg)
Intraperitoneal nicotine reduced hypersensitivity to noxious and non-noxious stimuli after chronic constriction injury and reduced mechanical and thermal hypersensitivity in dideoxycytidine and oxaliplatin neuropathy models.
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