The effects of p38 MAPK inhibition combined with G-CSF administration on the hematoimmune system in mice with irradiation injury.
MouseRadiationC57BL/6MaleIntraperitonealSB203580 15 mg/kg; G-CSF 1 microgram per mouseStarted after 6 Gy total body irradiation
Model: Sublethal 6 Gy total body irradiation at a dose rate of 0.78 Gy per minute
SB203580 and/or G-CSF enhanced recovery of peripheral blood counts and bone marrow mononuclear cells at 10 and 30 days after irradiation and increased progenitor clonogenicity and haematopoietic stem cell frequency at 30 days, although peripheral B and T cell recovery was unaffected.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.