Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
MixedRadiationTtp-null and wild-type on C57BL/6 background; separate C57BL/6 versus C3H comparisonMalen = n=6 mice per group per time point per genotype for TNF-alph…Added to cell culture medium; no in vivo administration of SB203580 reportedSB203580 1 micromolar in vitro; beta-TrCP1 siRNA 10 and 25…30 min before irradiation, or 1 h before irradiation for the clonogenic assay
Model: Single-dose thoracic irradiation of 15 Gy to the lungs; in vitro irradiation at 4 Gy using a Philips RT250 orthovoltage source at 250 kV
Ttp-null mice showed elevated basal (9.54 plus or minus 0.67 fold) and post-irradiation TNF-alpha (12.2 plus or minus 0.85 fold, p<0.02) with sustained acute lung inflammation, and SB203580 blocked radiation-induced TTP degradation and radioprotected lung macrophages (enhancement ratio 0.86) withou…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
MouseRadiationC57BL/6MaleIntraperitonealSB203580 15 mg/kg; G-CSF 1 microgram per mouseStarted after 6 Gy total body irradiation
Model: Sublethal 6 Gy total body irradiation at a dose rate of 0.78 Gy per minute
SB203580 and/or G-CSF enhanced recovery of peripheral blood counts and bone marrow mononuclear cells at 10 and 30 days after irradiation and increased progenitor clonogenicity and haematopoietic stem cell frequency at 30 days, although peripheral B and T cell recovery was unaffected.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
MouseRadiationC57BL/6MaleSubcutaneous injection in vivo; added to culture medium in vitro15 mg/kg body weight in vivo, diluted in DMSO; in vitro add…Starting 24 h after total-body irradiation in vivo; 30 min before irradiation f…
Model: Caesium-137 gamma irradiation: 4 Gy to bone marrow mononuclear cells in long-term culture and 6.5 Gy sublethal total-body irradiation in vivo, dose rate 2.4 Gy/min
SB203580 inhibited radiation-induced p38 activation, reduced SA-beta-galactosidase positivity and p16INK4a expression, increased CFU-GM production more than threefold in irradiated long-term cultures, and partially restored haematopoietic stem and progenitor cell frequencies and clonogenic function…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
