Regeneration of chronic tympanic membrane perforation using an EGF-releasing chitosan patch.
RatOtherSprague-DawleyFemalen = 23 treated and 24 control animalsLocal application of the patch to the perforation
Model: Chronic tympanic membrane perforation
Healing occurred in 13 of 23 treated animals (56.5 per cent) versus 4 of 24 untreated controls (20.8 per cent, p = 0.04), with better preserved histological features and thinner membranes than spontaneously healed tympanic membranes.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.