THERAPY DOSSIER · th-b8c845eb18ce

Epidermal growth factor-releasing chitosan patch scaffold

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01553708 ↗Injury indicationPHASE2/PHASE3completed

EGF with silver sulfadiazine cream versus silver zinc sulfadiazine on partial thickness burn wound healing

Deep partial thickness burn

Enrolment: 34 · Results not recorded

NCT01629199 ↗PHASE3completed

rhEGF in diabetic foot ulcer patients with uncontrolled diabetes mellitus

Diabetic foot ulcer

Enrolment: 176 · Results not recorded

NCT02554851 ↗PHASE3unknown

Intralesional rhEGF in subjects with diabetic foot ulcer

Foot ulcer, diabetic

Enrolment: 304 · Results not recorded

NCT05335720 ↗NAcompleted

EASYEF (rhEGF) in acute wound, split-thickness skin graft donor site

Skin graft scar · Split-thickness skin graft

Enrolment: 10 · Results not recorded

NCT03239457 ↗Phase not recordedcompleted

Heberprot-P (rhEGF) in advanced diabetic foot ulcer

Diabetic foot

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23627815 ↗2013Reported benefit

Regeneration of chronic tympanic membrane perforation using an EGF-releasing chitosan patch.

RatOtherSprague-DawleyFemalen = 23 treated and 24 control animalsLocal application of the patch to the perforation

Model: Chronic tympanic membrane perforation

Healing occurred in 13 of 23 treated animals (56.5 per cent) versus 4 of 24 untreated controls (20.8 per cent, p = 0.04), with better preserved histological features and thinner membranes than spontaneously healed tympanic membranes.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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