High-lipid enteral nutrition could partially mitigate inflammation but not lung injury in hemorrhagic shock rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 48 rats in four groupsEnteral gavage45 min before blood drawing and again at the end of resuscitation
Model: Haemorrhagic shock by blood drawing with mean blood pressure held at 40 to 45 mmHg for 120 min, followed by resuscitation with re-infusion of exsanguinated blood and saline
High-lipid enteral nutrition significantly reduced intestinal permeability and pulmonary tumour necrosis factor alpha and macrophage inflammatory protein-2, but did not change malondialdehyde, prostaglandin E2 or interleukin-6 and did not reduce histological lung injury.
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