THERAPY DOSSIER · th-ed1ed55bcb26

High-lipid enteral nutrition

Nutraceutical · Dietary intervention (high-lipid enteral nutrition); not a ChEMBL entity; no trial of this specific formulation identified

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Dietary intervention (high-lipid enteral nutrition); not a ChEMBL entity; no trial of this specific formulation identified
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23622726 ↗2013Mixed findings

High-lipid enteral nutrition could partially mitigate inflammation but not lung injury in hemorrhagic shock rats.

RatHaemorrhage/shockControlledSprague-DawleyMalen = 48 rats in four groupsEnteral gavage45 min before blood drawing and again at the end of resuscitation

Model: Haemorrhagic shock by blood drawing with mean blood pressure held at 40 to 45 mmHg for 120 min, followed by resuscitation with re-infusion of exsanguinated blood and saline

High-lipid enteral nutrition significantly reduced intestinal permeability and pulmonary tumour necrosis factor alpha and macrophage inflammatory protein-2, but did not change malondialdehyde, prostaglandin E2 or interleukin-6 and did not reduce histological lung injury.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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