Effect of free radical scavenger on c-jun activation in rats with crush syndrome.
RatCrushLimb / muscle crushWistarMaleIntraperitoneal100 mg/kgImmediately after withdrawal of crush pressure
Model: Crush syndrome produced by crushing the hind limbs with 15 kg pressure for 6 hours
Acute kidney injury peaked at 12 hours after crush; tempol significantly reduced phosphorylated c-jun compared with untreated crush animals, with parallel changes in renal malondialdehyde.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.