Tempol and coenzyme Q10

Tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal muscles: Involvement of superoxide.

Model: Tourniquet-induced hind limb ischaemia-reperfusion (3 h ischaemia, 4 h reperfusion)

Tempol or coenzyme Q10 reduced superoxide, infarct size and mitochondrial dysfunction after tourniquet ischaemia-reperfusion.

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Effect of free radical scavenger on c-jun activation in rats with crush syndrome.

Model: Crush syndrome produced by crushing the hind limbs with 15 kg pressure for 6 hours

Acute kidney injury peaked at 12 hours after crush; tempol significantly reduced phosphorylated c-jun compared with untreated crush animals, with parallel changes in renal malondialdehyde.

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Sustained oxidative stress causes late acute renal failure via duplex regulation on p38 MAPK and Akt phosphorylation in severely burned rats.

Model: Full-thickness scald burn over 40 per cent of total body surface area by immersion in 100 degrees Celsius water for 15 s, with lactated Ringer resuscitation at 4 ml/kg intraperitoneally immediately and 8 h after burn

Tempol and SB203580 reduced blood urea nitrogen, creatinine, tubular damage score and apoptosis at 72 h after burn, whereas Akt inhibitor IV worsened tubular apoptosis and renal dysfunction, indicating opposing roles for p38 MAPK and Akt.

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Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury

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Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat

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Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock

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Antioxidants attenuate acute toxicity of tumor necrosis factor-alpha induced by brain injury in rat

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Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats

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Protective effect of TEMPOL derivatives against light-induced retinal damage in rats

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Topical application of nitroxide protects radiation-induced alopecia in guinea pigs

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Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury

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