Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord.
MouseSpinal cord injuryUnspecifiedC57BL/6FemaleTransplantation into acutely, subacutely and chronically injured spinal cords
Model: Spinal cord injury studied at acute, subacute and chronic stages
Engrafted cells produced regenerative and neurotrophic molecules at all transplantation timings, most prominently in chronic transplantation, and differentiated into neurons and oligodendrocytes in the chronic environment, but locomotor function did not improve.
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