Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 7
7 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Study of the Safety and Efficacy of Human Central Nervous System Stem Cells (HuCNS-SC) Transplantation in Cervical Spinal Cord Injury
Cervical Spinal Cord Injury · Spine Injury · Cervical Spine Injury
Enrolment: 31 · Results not recorded
Safety and Preliminary Efficacy of Intramedullary Spinal Cord Transplantation of Human CNS Stem Cells (HuCNS-SC) in Subjects With Thoracic Spinal Cord Trauma
Thoracic Spinal Cord Injury · Spinal Cord Injury · Spinal Cord Injury Thoracic · Spinal Cord Trauma
Enrolment: 12 · Results not recorded
Safety and Efficacy of Autologous Neural Stem Cell Transplantation in Patients With Traumatic Spinal Cord Injury
Spinal Cord Injury
Enrolment: 30 · Results not recorded
Study to Evaluate the Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC Derived From hESC Line in AIS-A Level of Sub-acute SCI
Spinal Cord Injury, Acute · Spinal Cord Injury at C4 Level With Complete Lesion · Spinal Cord Injury at C5-C7 Level With Complete Lesion
Enrolment: 5 · Results not recorded
The Efficacy and Safety of NeuroRegen Scaffold Combined With Mesenchymal Stem Cells or Neural Stem Cells for Chronic Spinal Cord Injury Repair
Spinal Cord Injury
Enrolment: 30 · Results not recorded
A Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
Spinal Cord Injury (SCI)
Enrolment: 8 · Results not recorded
Long-term Follow-up Study of the Phase I/II Investigation of Intramedullary Spinal Cord Transplantation of HuCNS-SC in Subjects With Thoracic Spinal Cord Trauma
Spinal Cord Injury
Enrolment: 12 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseSpinal cord injuryUnspecifiedC57BL/6FemaleTransplantation into acutely, subacutely and chronically injured spinal cords
Model: Spinal cord injury studied at acute, subacute and chronic stages
Engrafted cells produced regenerative and neurotrophic molecules at all transplantation timings, most prominently in chronic transplantation, and differentiated into neurons and oligodendrocytes in the chronic environment, but locomotor function did not improve.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
