Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis.
RatChemical/toxinSprague-DawleyMaleIntragastricHalf an hour before establishment of the pancreatitis model
Model: Severe acute pancreatitis induced by injecting sodium taurocholate into the pancreatic and biliary duct
Emodin ameliorated pancreatic injury, lowered amylase and inflammatory cytokines and significantly reduced Bip, IRE1 alpha, TRAF2 and ASK1 expression and JNK and p38 MAPK phosphorylation at all time points.
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