Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.
RatTBIUnspecifiedSprague-Dawleymalen = 20 rats across four groupssystemic and brain coolingbrain temperature reduced to 33 degrees Celsius, normotherm…early hypothermia induced 30 min before craniotomy; late hypothermia induced 30…
Model: Acute subdural haematoma with subsequent craniotomy and decompression
Hypothermia induced early significantly reduced microdialysate ubiquitin carboxyl-terminal hydrolase L1 concentration, suggesting reduced neuronal cell damage from reperfusion injury after haematoma removal. Microdialysate UCH-L1 appeared to be a sensitive biomarker of neuronal injury.
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