THERAPY DOSSIER · th-18d8c6335e18

Mild therapeutic hypothermia to 33 degrees Celsius

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03442608 ↗Injury indicationNAunknown

Efficacy and Safety of Long-term Therapeutic Hypothermia in Poor-grade Aneurysmal Subarachnoid Hemorrhage

Hypothermia · Aneurysmal Subarachnoid Hemorrhage

Enrolment: 200 · Results not recorded

NCT02991690 ↗Injury indicationNArecruiting

Systemic Hypothermia in Acute Cervical Spinal Cord Injury: Prospective Multi-center Case Controlled Study

Spinal Cord Injury, Acute

Enrolment: 120 · Results not recorded

NCT02411877 ↗PHASE2withdrawn

REperfusion With Cooling in CerebraL Acute IscheMia II

Ischemic Stroke · Hypothermia

Enrolment: 0 · Results not recorded

NCT01544530 ↗PHASE2terminated

Mild-to-moderate Therapeutic Hypothermia as In-vivo Organ Preservation Strategy in Brain-dead Donors

Organ Transplantation From Brain-dead Donors

Enrolment: 4 · Results not recorded

NCT01585597 ↗PHASE1completed

Mild Induced Hypothermia After Endovascular Revascularization in Acute Ischemic Stroke

Stroke, Acute

Enrolment: 20 · Results not recorded

NCT01186614 ↗PHASE1unknown

Refractory Out-Of-Hospital Cardiac Arrest Treated With Mechanical CPR, Hypothermia, ECMO and Early Reperfusion

Cardiac Arrest

Enrolment: 24 · Results not recorded

NCT02826057 ↗NAunknown

The Complement Lectin Pathway in Patients Resuscitated After Cardiac Arrest (TTM 33 degrees Celsius)

Out-of-Hospital Cardiac Arrest · Post Cardiac Arrest Syndrome

Enrolment: 82 · Results not recorded

NCT04217551 ↗NAcompleted

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)

Cardiac Arrest, Out-Of-Hospital · Hypothermia, Induced

Enrolment: 1158 · Results not recorded

NCT01728649 ↗NAwithdrawn

Phase 2 Study of Mild Hypothermia With Acute Cerebral Vascular Reperfusion in Acute Ischemic Stroke

Ischemic Stroke · Hypothermia

Enrolment: 0 · Results not recorded

NCT00147030 ↗NAcompleted

Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy (TOBY)

Asphyxia Neonatorum · Encephalopathy

Enrolment: 325 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23564108 ↗2013Reported benefit

Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.

RatTBIUnspecifiedSprague-Dawleymalen = 20 rats across four groupssystemic and brain coolingbrain temperature reduced to 33 degrees Celsius, normotherm…early hypothermia induced 30 min before craniotomy; late hypothermia induced 30…

Model: Acute subdural haematoma with subsequent craniotomy and decompression

Hypothermia induced early significantly reduced microdialysate ubiquitin carboxyl-terminal hydrolase L1 concentration, suggesting reduced neuronal cell damage from reperfusion injury after haematoma removal. Microdialysate UCH-L1 appeared to be a sensitive biomarker of neuronal injury.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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