Administration of MS-275 improves cognitive performance and reduces cell death following traumatic brain injury in rats.
RatTBIFluid percussionSprague-DawleyMaleSystemic (route not further specified)15 and 45 mg/kgStarting 30 minutes after lateral fluid percussion injury
Model: Lateral fluid percussion injury at approximately 2.15 atmospheres
Both doses improved Morris water maze performance, and 45 mg/kg reduced degenerating neurons in the ipsilateral CA2-3 hippocampus at 24 hours, with only a non-significant trend for increased neuronal survival at 14 days. Note that this publication has been retracted.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.