Entinostat plus clofarabine in poor-risk ALL
Acute lymphoblastic leukaemia
Enrolment: 27 · Results not recorded
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Drug · Histone deacetylase inhibitor (INHIBITOR, direct interaction, disease efficacy true)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute lymphoblastic leukaemia
Enrolment: 27 · Results not recorded
Acute myeloid leukaemia · Myelodysplastic syndromes
Enrolment: 24 · Results not recorded
Hodgkin's lymphoma
Enrolment: 49 · Results not recorded
Non-small cell lung cancer
Enrolment: 143 · Results not recorded
Non-small cell lung carcinoma
Enrolment: 17 · Results not recorded
Metastatic breast cancer
Enrolment: 50 · Results not recorded
Bladder cancer
Enrolment: 29 · Results not recorded
Ovarian carcinoma · Fallopian tube cancer
Enrolment: 3 · Results not recorded
Drug interaction · Healthy volunteer
Enrolment: 26 · Results not recorded
Healthy volunteers
Enrolment: 66 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Lateral fluid percussion injury at approximately 2.15 atmospheres
Both doses improved Morris water maze performance, and 45 mg/kg reduced degenerating neurons in the ipsilateral CA2-3 hippocampus at 24 hours, with only a non-significant trend for increased neuronal survival at 14 days. Note that this publication has been retracted.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.