Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats.
RatTBIUnspecifiedWistarIntraperitonealProgesterone 8 mg/kg; magnesium sulfate 150 mg/kgImmediately after induction of traumatic brain injury
Model: Contusion injury of the immature brain
Combined progesterone and magnesium sulfate reduced trauma-induced neuronal death and acute hippocampal and prefrontal apoptosis, raised brain VEGF above either drug alone, and improved the spatial memory deficits that appeared later in life.
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