Tympanic membrane repair using silk fibroin and acellular collagen scaffolds.
Guinea pigWoundAlbinon = 72 guinea pigs in four experimental groups (n = 18 per grou…Onlay myringoplasty (local placement over the perforation)At the time of perforation
Model: Acute perforation of the right tympanic membrane, repaired by onlay myringoplasty
Tympanic membranes treated with silk fibroin or acellular collagen scaffolds closed earlier, showed a trilaminar structure of more uniform thickness, and recovered hearing faster than paper patch or untreated controls.
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