PRECLINICAL PUBLICATION · 2013

Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

N-acetylcysteine

PMID 23526214 ↗2013Mixed findings

Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation.

MouseRadiation

Model: 20 Gy single-fraction thoracic irradiation in wild-type and Mif knockout mice

Glutathione reduced ester protected aged Mif knockout mice from radiation-induced lung injury whereas N-acetyl cysteine did not, implicating MIF-dependent Nrf2 signalling in age-related susceptibility.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.