Depression of neuronal activity by sedatives is associated with adverse effects after brain injury.
RatTBIControlled cortical impactSprague-DawleyMaleIsoflurane by inhalation; midazolam and flumazenil route not statedIsoflurane at minimum alveolar concentration 1.0 and 1.67Treatment began two hours before controlled cortical impact injury
Model: Controlled cortical impact injury
Deep sedation with isoflurane at minimum alveolar concentration 1.67 or with midazolam increased apoptotic cell counts by 14.8 per cent and 18.0 per cent respectively and worsened neurological outcome, and flumazenil reversed the midazolam effect.
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