Attenuating heatstroke-induced acute lung inflammation, edema, and injury in rats by exercise preconditioning.
RatOtherWistarMaleNot applicable (physical training)Treadmill running 30 minutes at 20 m/min, 30 minutes at 30…Preconditioning over 3 weeks before heat exposure
Model: Heatstroke induced by a 43 degrees C heating pad for 68 minutes under general anaesthesia
Exercise preconditioning induced lung HSP-70 overexpression and significantly attenuated heat-induced pulmonary oedema, inflammation and ischaemic and oxidative damage. HSP-70 antibodies reduced lung HSP-70 and abolished much of this protection, supporting an HSP-70-mediated mechanism.
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