THERAPY DOSSIER · th-378ebee9f1af

Exercise preconditioning (treadmill running)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06342063 ↗Injury indicationNAcompleted

Preoperative blood flow restriction training in patients undergoing ACL reconstruction

ACL injury

Enrolment: 32 · Results not recorded

NCT01164618 ↗PHASE2unknown

Biology of chronic preconditioning: genomic and physiologic mechanisms (remote ischaemic preconditioning and exercise)

Ischaemic preconditioning

Enrolment: 12 · Results not recorded

NCT06735378 ↗NArecruiting

Exercise preconditioning to protect against dialysis-induced cardiac injury in haemodialysis patients

Haemodialysis · Cardioprotection

Enrolment: 30 · Results not recorded

NCT02842658 ↗NAcompleted

Aerobic interval exercise preconditioning to prevent complications of anthracycline-based breast cancer chemotherapy

Breast cancer

Enrolment: 1 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23511144 ↗2013Reported benefit

Attenuating heatstroke-induced acute lung inflammation, edema, and injury in rats by exercise preconditioning.

RatOtherWistarMaleNot applicable (physical training)Treadmill running 30 minutes at 20 m/min, 30 minutes at 30…Preconditioning over 3 weeks before heat exposure

Model: Heatstroke induced by a 43 degrees C heating pad for 68 minutes under general anaesthesia

Exercise preconditioning induced lung HSP-70 overexpression and significantly attenuated heat-induced pulmonary oedema, inflammation and ischaemic and oxidative damage. HSP-70 antibodies reduced lung HSP-70 and abolished much of this protection, supporting an HSP-70-mediated mechanism.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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