Localized leptin release may be an important mechanism of curcumin action after acute ischemic injuries.
MouseIschaemia-reperfusionIntestinal / mesentericMaleIntraperitoneal
Model: Intestinal ischaemia/reperfusion injury
Curcumin significantly improved survival and reduced intestinal pathological injury, water content, malondialdehyde, interleukin-1beta and interleukin-6, while increasing superoxide dismutase. Reduced leptin and Ob-Rb were restored and ERK1/2 and p38 MAPK signalling normalised, with the effect reve…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.