Propofol administration modulates AQP-4 expression and brain edema after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMaleAdministered within a short time after traumatic brain injury
Model: Controlled cortical impact traumatic brain injury
Propofol given shortly after controlled cortical impact significantly reduced brain oedema and suppressed aquaporin-4 expression, in association with lower interleukin-1beta and tumour necrosis factor-alpha. In cultured astrocytes propofol blocked cytokine-driven aquaporin-4 induction by inhibiting…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.