A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.
MouseChemical/toxinC57BL/6JFemalen = n = 6 to 7 mice per group for lavage differential counts; n…Oropharyngeal aspiration (inhalation)100 ng RvD1 or 100 ng 17R-RvD1 in 40 microlitres salinePre-treatment model: on day 0 and 1 hour before the first smoke exposure on day…
Model: Acute cigarette smoke-induced lung inflammation, dilute mainstream smoke for 1 hour twice daily for 3 days at nominal 450 mg/m3 total suspended particulate; the resolution model used 2 hours per day on days 1 to 3
RvD1 given concurrently with cigarette smoke significantly reduced lavage neutrophils, total protein, KC, MIP-2, interleukin-1beta, interleukin-6, prostaglandin E2 and COX-2, and increased interleukin-10, while promoting M2 macrophage polarisation and neutrophil efferocytosis. A single dose of 17R-…
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