Protective effects of l-glutamine on the bladder wall of rats submitted to pelvic radiation.
RatRadiationWistarMalen = 8 animals per groupOral nutritional supplementation0.65 g/kg body weight per dayGiven around the radiation session, with animals killed 7 or 15 days after irra…
Model: Single 10 Gy radiation session aimed at the pelvico-abdominal region, causing bladder wall injury
Radiation reduced lamina propria blood vessel density by 48 percent at day 7 (p < 0.05) and urothelial thickness by 25 percent at day 15 (p < 0.05), and glutamine largely prevented both changes (p < 0.02 and p < 0.01 respectively). Glutamine did not prevent the 35 percent increase in epithelial cel…
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