The fibrotic role of phosphatidylinositol-3-kinase/Akt pathway in injured skeletal muscle after acute contusion.
MouseCrushLimb / muscle crushC57BL/6Male
Model: Acute contusion of skeletal muscle in a mouse model
PI3K inhibition reduced expression of fibrosis markers and scar area in contused skeletal muscle and improved both fast-twitch and tetanic strength, indicating that PI3K-Akt-mTOR activation promotes collagen production and scarring after contusion.
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