Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.
Model: Ten minutes of severe global forebrain ischaemia by modified four-vessel occlusion (electrocauterisation of vertebral arteries and temporary clipping of both common carotid arteries) followed by reperfusion; ischaemic preconditioning of 2 minutes followed 72 hours later by 10 minutes ischaemia; in vitro 3 hours oxygen glucose deprivation with 24 hours reperfusion in primary rat hippocampal and cortical neurons from E18 embryos
Hamartin was selectively induced in ischaemia-resistant CA3 neurons and in CA1 after ischaemic preconditioning. TSC1 knockdown increased cell death after oxygen glucose deprivation by 34 plus or minus 6.7 per cent, reduced CA3 neuronal density after ischaemia to 105.9 plus or minus 4.0 versus 139.2…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.