Evidence & regulatory context
- Mechanism
- Gene therapy (lentiviral hamartin/TSC1 overexpression and shRNA); not a ChEMBL entity, preclinical
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalen = n = 5 per group for the proteomic comparison (sham ischaemi…Intrahippocampal stereotaxic injection in vivo (3.8 mm posterior and 3.8 mm lateral to bregma, 3.0 mm below dura, 0.2 microlitres per minute); lentiviral transduction of cultures in vitroIn vivo stereotaxic injection of 5.0 microlitres containing…Lentiviral vectors administered 14 days before ischaemia; cultures transduced a…
Model: Ten minutes of severe global forebrain ischaemia by modified four-vessel occlusion (electrocauterisation of vertebral arteries and temporary clipping of both common carotid arteries) followed by reperfusion; ischaemic preconditioning of 2 minutes followed 72 hours later by 10 minutes ischaemia; in vitro 3 hours oxygen glucose deprivation with 24 hours reperfusion in primary rat hippocampal and cortical neurons from E18 embryos
Hamartin was selectively induced in ischaemia-resistant CA3 neurons and in CA1 after ischaemic preconditioning. TSC1 knockdown increased cell death after oxygen glucose deprivation by 34 plus or minus 6.7 per cent, reduced CA3 neuronal density after ischaemia to 105.9 plus or minus 4.0 versus 139.2…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
