Curcumin improves the survival rate after a massive hepatectomy in rats.
RatOtherFischer 344 (inbred F344)Malen = 13 rats per group (curcumin and vehicle)Oral340 mg/kgPretreatment, for 7 consecutive days before surgery and again 2 hours before th…
Model: Ninety per cent (massive) hepatectomy causing acute liver failure
Six of 13 curcumin-pretreated rats survived, whereas all 13 vehicle-pretreated rats died within 2 days of massive hepatectomy. Lobular architecture remained relatively preserved without necrosis in curcumin-treated animals, and haem oxygenase-1 protein was elevated preoperatively and remained high…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.