HMGB1 activity inhibition alleviating liver injury in heatstroke.
RatOtherWistarMalePretreatment, before exposure to heat stress
Model: Heatstroke induced by exposure to a high-temperature and high-humidity environment, with liver injury as the target organ
HMGB1 was elevated in plasma and liver cytoplasm of heatstroke rats alongside raised transaminases. Pretreatment with anti-HMGB1 monoclonal antibody alleviated hepatic histopathological damage, lowered plasma alanine and aspartate aminotransferase, and significantly suppressed tumour necrosis facto…
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