Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model.
RatOtherWistar (specific pathogen-free)Malen = Survival: 23 per heatstroke group and 8 sham; blood samplin…Platinum electrode placed under the exposed left cervical vagus nerve, connected to a Master-8 pulse stimulatorConstant voltage 10 V, pulse width 2 ms, frequency 5 Hz, ap…Immediately after completion of the 30-minute heat stress
Model: Anaesthetised rat heatstroke model: core temperature raised approximately 1 degree C every 5 minutes and maintained at 41.5 plus or minus 0.2 degrees C for 30 minutes, then passive recovery at 24 degrees C with subcutaneous saline 35 ml/kg to prevent dehydration
Seven-day survival was 61 per cent (14 of 23) with vagus nerve stimulation versus 26 per cent (6 of 23) without (p = 0.016, log-rank). Stimulation significantly reduced serum tumour necrosis factor alpha at 6 hours, interleukin-6 at 3 and 6 hours, soluble thrombomodulin at 3 and 6 hours and soluble…
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