Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
A Trial of Rehabilitation Paired with VNS for Motor Function Recovery in Post-ICH Patients (Recovery Study)
Spontaneous Intracerebral Hemorrhage · Motor Function · Upper Extremity Injury · Rehabilitation · Vagus Nerve Stimulation
Enrolment: 10 · Results not recorded
Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Stroke · Chronic Stroke · Upper Extremity Paresis · Ischemic Stroke · Hemorrhagic Stroke
Enrolment: 42 · Results not recorded
Mechanisms of Paired Vagus Nerve Stimulation (VNS) in Chronic Stroke: a Randomized, Blinded, Sham-controlled Mechanistic Trial
Chronic Stroke
Enrolment: 4 · Results not recorded
Evaluation of Noninvasive Vagus Nerve Stimulation on Functional Status in Ischemic Stroke
Stroke, Ischemic · Hemiplegia · Hemiparesis;Poststroke/CVA
Enrolment: 80 · Results not recorded
Combined Effects of Transcutaneous Vagus Nerve Stimulation and Modified Constraint Induced Movement Therapy on Upper Extremity Function, Cognition and Quality of Life in Individual With Chronic Stroke
Stroke · Cerebrovascular Accident
Enrolment: 50 · Results not recorded
Effect of Trans-auricular Vagus Nerve Stimulation on Plasticity Biomarkers, Interleukin-6 and Motor Performance Post Stroke
Stroke · Motor Disorders
Enrolment: 80 · Results not recorded
Comparative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation on Upper Limb Function, Cognition and Quality of Life in Subacute Stroke Patients
Stroke · Stroke, Acute
Enrolment: 54 · Results not recorded
Investigate the Anti-pain Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Patients With Chronic Post-stroke Upper Extremity Pain
Stroke · Pain
Enrolment: 15 · Results not recorded
Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry
Chronic Ischemic Stroke
Enrolment: 40 · Results not recorded
Effects of Transcutaneous Vagus Nerve Stimulation With Virtual Reality on Upper Limb Functions in Post-stroke Patients
Stroke
Enrolment: 46 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatOtherWistar (specific pathogen-free)Malen = Survival: 23 per heatstroke group and 8 sham; blood samplin…Platinum electrode placed under the exposed left cervical vagus nerve, connected to a Master-8 pulse stimulatorConstant voltage 10 V, pulse width 2 ms, frequency 5 Hz, ap…Immediately after completion of the 30-minute heat stress
Model: Anaesthetised rat heatstroke model: core temperature raised approximately 1 degree C every 5 minutes and maintained at 41.5 plus or minus 0.2 degrees C for 30 minutes, then passive recovery at 24 degrees C with subcutaneous saline 35 ml/kg to prevent dehydration
Seven-day survival was 61 per cent (14 of 23) with vagus nerve stimulation versus 26 per cent (6 of 23) without (p = 0.016, log-rank). Stimulation significantly reduced serum tumour necrosis factor alpha at 6 hours, interleukin-6 at 3 and 6 hours, soluble thrombomodulin at 3 and 6 hours and soluble…
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