Erythropoietin neuroprotection is enhanced by direct cortical application following subdural blood evacuation in a rat model of acute subdural hematoma.
RatTBIUnspecifiedSprague-DawleyMaleIntravenous, or direct cortical (topical) application after haematoma evacuationIntravenous 200, 2000 or 20,000 IU per rat; cortical surfac…Intravenous at 15 min post-injury; cortical application at 70 min post-injury a…
Model: Acute subdural haematoma induced by subdural infusion of 400 microlitres autologous venous blood, with surgical evacuation of the haematoma
Intravenous EPO at 200 and 2000 IU reduced lesion volume from 38.2 to 28.5 and 22.2 cubic millimetres and cortical 0.02 IU reduced it from 36.0 to 11.2 cubic millimetres, whereas the highest doses by either route enlarged lesions to 46.5 and 67.9 cubic millimetres and 20,000 IU raised intracranial…
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