CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.
MouseEndotoxin/LPSC57BL/6, 129 strain, cd73-/- knockout, Rag-/-MaleAdoptive transfer into Rag-/- recipients
Model: Intratracheal lipopolysaccharide-induced acute lung injury with peak injury at day 3 and resolution by day 14
Transfer of wild-type regulatory T cells supported normal resolution of acute lung injury whereas cd73-deficient cells did not, and cd73 deletion increased mortality from 0 per cent in wild-type to 40 per cent.
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