THERAPY DOSSIER · th-a2f915a1e487

Adoptive transfer of CD73-expressing regulatory T cells; pegylated adenosine deaminase as a pharmacological probe

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04661254 ↗NAunknown

Treg cell therapy in liver and kidney transplantation: preclinical validation of in vitro amplified Treg batches

Kidney Transplantation · Liver Transplantation

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23413361 ↗2013Reported benefit

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.

MouseEndotoxin/LPSC57BL/6, 129 strain, cd73-/- knockout, Rag-/-MaleAdoptive transfer into Rag-/- recipients

Model: Intratracheal lipopolysaccharide-induced acute lung injury with peak injury at day 3 and resolution by day 14

Transfer of wild-type regulatory T cells supported normal resolution of acute lung injury whereas cd73-deficient cells did not, and cd73 deletion increased mortality from 0 per cent in wild-type to 40 per cent.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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