Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain.
RatOtherSprague-DawleyMaleIntrathecal injectionEarly after nerve injury
Model: Peripheral nerve injury model of neuropathic pain with tactile allodynia
Intrathecal FK-506 or 11R-VIVIT given early after nerve injury attenuated the development of tactile allodynia and reduced NFATc4 and CCR2 mRNA in the dorsal root ganglia.
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