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PRECLINICAL PUBLICATION · 2013

Effect of a single subacromial prednisolone injection in acute rotator cuff tears in a rat model.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23370982 ↗2013Mixed findings

Effect of a single subacromial prednisolone injection in acute rotator cuff tears in a rat model.

RatOtherSprague-DawleyMalen = 40 rats in 2 groupsSubacromial injectionSingle dose, amount not statedAt the time of tendon defect creation

Model: Surgically created full-thickness defect of the unilateral infraspinatus tendon, an acute rotator cuff tear

Subacromial methylprednisolone raised the type III to type I collagen ratio at 7 days and increased aggrecan and fibronectin at 3 days, suggesting early interference with healing, but these alterations normalised after the early inflammatory phase.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.