Injection time-dependent effect of adult human bone marrow stromal cell transplantation in a rat model of severe traumatic brain injury.
RatTBIFluid percussionSprague-Dawleyn = Day 1 group n=12, day 7 group n=8, control n=7, plus 9 addi…Transplantation into the corpus callosum ipsilateral to the injury siteDay 1 or day 7 after injury
Model: Lateral fluid percussion severe traumatic brain injury
Transplantation on day 7 improved behavioural test scores at all time points and lowered GFAP staining at day 42 relative to day 1 injection, but no significant differences were found on other tests, so therapeutic potential was limited.
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