Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 6
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Phase I Pilot Study to Evaluate the Security of Local Administration of Autologous Stem Cells Obtained From the Bone Marrow Stroma, in Traumatic Injuries of the Spinal Cord
Spinal Cord Injury
Enrolment: 12 · Results not recorded
A Phase IIa, Open Label, Dose-escalating Clinical Study to Evaluate Transplantation of Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF) in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Enrolment: 14 · Results not recorded
Explorative Trial to Investigate the Safety and Clinical Effects of Autologous Mesenchymal Bone Marrow Stem Cells (MSC) Following Their Intrathecal and Intravenous Administration in Severe Cases of Multiple Sclerosis
Multiple Sclerosis
Enrolment: 24 · Results not recorded
Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation: A Phase I Study
Osteodysplasia
Enrolment: 8 · Results not recorded
Bone Regeneration Using Bone Marrow Stromal Cells
Bone Disease · Craniofacial Abnormality · Healthy
Enrolment: 54 · Results not recorded
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cells (BMSC) Products
Bone Marrow Stromal Cells
Enrolment: 65 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatTBIFluid percussionSprague-Dawleyn = Day 1 group n=12, day 7 group n=8, control n=7, plus 9 addi…Transplantation into the corpus callosum ipsilateral to the injury siteDay 1 or day 7 after injury
Model: Lateral fluid percussion severe traumatic brain injury
Transplantation on day 7 improved behavioural test scores at all time points and lowered GFAP staining at day 42 relative to day 1 injection, but no significant differences were found on other tests, so therapeutic potential was limited.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
