Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats.
RatOtherSprague-Dawleyn = 50 rats in 5 groups of n=10Continuous intravenous infusion via left femoral vein cannulaDexmedetomidine 5.0 micrograms/kg per hour; yohimbine 0.2 m…Beginning 30 minutes after blunt chest trauma
Model: Bilateral blunt chest trauma producing pulmonary contusion
Dexmedetomidine improved haemodynamics, reduced alveolar inflammatory cell infiltration and lowered plasma TNF-alpha and IL-1beta and lung NF-kappaB activation, and these effects were significantly reversed by yohimbine.
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