Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6Male100 mg/kg5 minutes after injury
Model: Closed-head controlled cortical impact mild traumatic brain injury with impact on the sagittal suture midway between bregma and lambda, depth 2.0 mm, velocity 4 m/s and dwell time 100 milliseconds
Resveratrol reduced Iba1 microglial activation in the cerebral cortex, corpus callosum and dentate gyrus and lowered hippocampal IL-6 and IL-12 at 72 hours after mild traumatic brain injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.