PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2013

Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23354240 ↗2013Reported benefit

Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury.

MouseTBIControlled cortical impactC57BL/6Male100 mg/kg5 minutes after injury

Model: Closed-head controlled cortical impact mild traumatic brain injury with impact on the sagittal suture midway between bregma and lambda, depth 2.0 mm, velocity 4 m/s and dwell time 100 milliseconds

Resveratrol reduced Iba1 microglial activation in the cerebral cortex, corpus callosum and dentate gyrus and lowered hippocampal IL-6 and IL-12 at 72 hours after mild traumatic brain injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.